Middlemarch by George Eliot

Peopling its landscape are Dorothea Brooke, a young idealist whose search for intellectual fulfilment leads her into a disastrous marriage to the pedantic scholar Casaubon; the charming but tactless Dr Lydgate, whose marriage to the spendthrift beauty Rosamund and pioneering medical methods threaten to undermine his career; and the religious hypocrite Bulstrode, hiding scandalous crimes from his past.